Where'd You Go, Bernadette
Maria Semple

Then Bernadette disappears. It began when Bee aced her report card and claimed her promised reward: a family trip to Antarctica. But Bernadette's intensifying allergy to Seattle—and people in general—has made her so agoraphobic that a virtual assistant in India now runs her most basic errands. A trip to the end of the earth is problematic.
To find her mother, Bee compiles email messages, official documents, secret correspondence—creating a compulsively readable and touching novel about misplaced genius and a mother and daughter's role in an absurd world.