Dr. Joanne Rivers thinks she's found the cure to Genetic Sexual attraction. Her theory is that it's caused by a simple chemical imbalance that can be controlled through medication. The downside is that in order to prove it she needs to inject a volunteer with a serum designed to create that imbalance. When her three longtime best friends who are also her partners in the practice,tell her it's too risky, Joanne decides to inject herself and see if it sparks that forbidden sexual attraction. After all, what's the worst that can happen?